Partnering with world-renowned scientists to advance Lyme research.
Professor and Director: TGen Pathogen Genomics Division
Regents Professor & Director: NAU Center for Microbial Genetics & Genomics
Former Chairman: National Science Advisory Board for Biosecurity
Paul Keim is a Professor and Director of the Pathogen Genomics Division, a joint program between the Translational Genomics Research Institute (TGen) and the Northern Arizona University (NAU), which results in a unified approach to protecting America against dangerous pathogens, in particular Bacillus anthracis (anthrax). The Pathogen Genomics Program core missions include: Bolstering of biodefense through improved forensic analysis. Understanding interactions between man and microbe to develop new therapeutics and diagnostics that will alleviate the human ailments caused by dangerous pathogens. Developing an improved understanding of disease movement to reduce and control the incidence of disease. Building on the existing work at NAU and the genomics tools at TGen, the Pathogen Genomics Program will provide high-resolution genomic forensic analysis of biothreat pathogenic agents such as Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), Brucella melitensis (brucellosis), and Coxiella burnett (Q fever). These are considered the most dangerous of the bacterial bioterrorism and bioweapons agents. The Program also will build upon our collaborations with state and federal agencies in developing molecular identification tools for public health related pathogens like E. coli, Salmonella, Listeria, and tuberculosis, which cause illness in billions of individuals worldwide. TGen will continue to create the scientific base to launch responses for acts of bioterrorism and to develop strategies to optimize public health management. In addition to development of advanced assays for dangerous pathogens, the Program focuses on understanding the interaction between the pathogen and its environment (ecology), the movement of the pathogen and the associated ailments though a population (epidemiology), and the changes associated with the propagation of the pathogen over time (evolution).
Director: Programs & Operations TGen North
David Engelthaler is the Director of Programs and Operations for TGen North. David is currently overseeing research projects involving rapid antibiotic resistance detection; development of novel genotyping techniques for molecular epidemiology and microbial forensics; fungal phylogenetics; and more. A major focus of this works involves adapting and advancing the use of next generation sequencing tools for infectious disease research and health care. David also oversees the application of the above research in real-life disease outbreak investigations, both natural and man-made. Prior to joining TGen, David was the State Epidemiologist for Arizona, at the Arizona Department of Health Services. He has also served as the Arizona Bioterrorism Coordinator and as biologist for the federal Centers for Disease Control and Prevention. David received a Masters Degree in Microbiology from Colorado State University and an undergraduate degree in biology from Northern Arizona University.